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However,the primary and secondary lysosome hypothesis has proved tohave little validity as new research data allow a better under-standing ofthedetailsofprotein secretorypathways and thefateofendocytoticvesicles. There have been tremendousadvances in blood gas technology including min-iaturization of components, improved qualitycontrol, simpli?ed maintenance techniques,reduced sample size, decreased throughput time,and portability

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-blockers are less effective as antihypertensive inAfro-Caribbeans. Bell DW, Varley JM, Szydlo TE et al (1999) Heterozygous germ line hCHK2 mutations inLi-Fraumeni syndrome

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