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The crystal structure of acompound analogous to YH265, but based on an imidazole rather than pyrazolescaffold, bound to MDMX has been solved (PDB: MDMX: 3LBJ, MDM2: 3LBK)and represents the only MDMX small molecule co-crystal structure so far [see arecent review of available structural information on MDM2/X-inhibitor interactionfor more details [77, 85, 86]]. The peptide chain of AVPis rapidly cleaved enzymatically in many organs,especially in liver and kidney; plasma t? is short~25 min.

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