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In a recent study , weevaluated the effects of GST polymorphisms on azathioprine metabolism in a cohort of 75young patients (median age 15.2 years, 36 females) with IBD (46 Crohn’s disease, 29ulcerative colitis) tolerant to azathioprine therapy (taking azathioprine for more than 3months). The uptake of vapor is determined by thealveolar ventilation (Q ), cardiac output (Q ), blood:air partition coefficient, and the concentration gradient between arterial and venouspulmonary blood (C and C ). These extrapyramidalelements are addressed in Chapter 12.1, “Parkinson’sDisease,” and Chapter 12.2, “Essential Tremor and OtherTremor Disorders,” respectively.
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