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Based on 1994 data, delirium complicates hospi-tal stays for more than 2.3 million older persons per year,occurs during 17.5 million inpatient days, and accountsfor more than billion of Medicare expenditures. The excess ofcatecholamines is inactivated by the enzymecatechol O-methyltransferase (COMT) or is destroyedby another enzyme found on the outer mitochondrial mem-brane purchase provigil monoamine oxidase (MAO). The BZDs alsoenhance GABA binding to GABAA receptor.The GABAA antagonist bicuculline antagonizesBZD action in a noncompetitive manner

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